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During concomitant use of CELEBREX and ACE-inhibitors or ARBs in patients who are elderly, volume-depleted, or have impaired renal function, monitor for signs of worsening renal function [see When these drugs are administered concomitantly, , patients should be adequately hydrated. The analgesic effects of the drugs had been exaggerated. During concomitant use of CELEBREX and digoxin, monitor serum digoxin levels.

Among the most common reasons for discontinuation due to adverse events in the CELEBREX treatment groups were dyspepsia and abdominal pain (cited as reasons for discontinuation in 0. If a serious GI adverse event is suspected, promptly initiate evaluation and treatment, and discontinue CELEBREX until a serious GI adverse event is ruled out. Reuben was also a former paid spokesperson for Pfizer. Table 1 lists all adverse events, regardless of causality, occurring in ≥2% of patients receiving CELEBREX from 12 controlled studies conducted in patients with OA or RA that included a placebo and/or a positive control group. The court ruled in favor of Searle, holding in essence that the University had claimed a method requiring, yet provided no written description of, a compound that could inhibit COX-2 and therefore the patent was invalid.

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I: critical appraisal of existing treatment guidelines and systematic review of current research evidence". COX-2 in humans using a compound, without actually disclosing what that compound might be) covered drugs such as celecoxib. Concomitant use of CELEBREX and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity (see the pemetrexed prescribing information).

Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, Taubert KA (March 2007). Celecoxib has not been studied in patients under the age of 2 years, in patients with body weight less than 10 kg (22 lbs), and in patients with active systemic features. Published animal studies have shown that administration of prostaglandin synthesis inhibitors has the potential to disrupt prostaglandin mediated follicular rupture required for ovulation. Like all NSAIDs on the US market, celecoxib carries an FDA-mandated "black box warning" for cardiovascular and gastrointestinal risk. WARNINGS AND CELEBREX is contraindicated in the setting of coronary artery bypass graft (CABG) surgery.

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